外泌体在眼科疾病诊断与治疗中的研究进展

沈文清; 徐芳; 罗淑敏; 路鹏鹏; 蔡超; 李伟华

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DOI:10.13429/j.cnki.cjcr.2025.05.029

中国临床研究英文版:2025,38(5):792-796

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外泌体在眼科疾病诊断与治疗中的研究进展

沈文清¹, 徐芳², 罗淑敏², 路鹏鹏², 蔡超³, 李伟华²

(1.首都医科大学，北京 100069;2.首都医科大学附属北京佑安医院肝病研究所，北京 100069;3.内蒙古医科大学附属医院，内蒙古呼和浩特 0100301)

Research progress of exosomes in the diagnosis and treatment of ophthalmic diseases

SHEN Wenqing¹, XU Fang², LUO Shumin², LU Pengpeng², CAI Chao³, LI Weihua²

(1.Capital Medical University, Beijing 100069, China;2.Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medicine University, Beijing 100069, China;3.The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 0100301, China)

摘要

本文已被：浏览 45次下载 36次
Received:March 04, 2024 Published Online:May 20, 2025

中文摘要: 外泌体是细胞分泌的直径为 30~150 nm的纳米级囊泡，由脂双层、蛋白质和遗传物质组成，可以向靶细胞递送生物活性分子，在细胞通讯、免疫调节、炎症反应等方面具有关键作用，与多种人类疾病有关。近几年，随着外泌体在眼科疾病方面研究的不断深入，其在眼科疾病中的重要作用日益受到重视。本文总结了目前外泌体在干燥综合征、青光眼、年龄相关性黄斑变性、糖尿病视网膜病变和葡萄膜黑色素瘤中诊断和治疗的研究进展，重点关注外泌体作为生物标记物和治疗载体的应用。

中文关键词: 外泌体干燥综合征青光眼年龄相关性黄斑病变糖尿病视网膜病变

Abstract:Exosomes are nanoscale vesicles secreted by cells, with a diameter ranging from 30 nm to 150 nm. Composed of lipid bilayers, proteins, and genetic material, they can deliver bioactive molecules to target cells, playing a crucial role in cell communication, immune regulation, inflammation, and other processes. Exosomes are associated with various human diseases. In recent years, as research on exosomes in ophthalmic diseases has progressed, their significant role in ophthalmic diseases has been increasingly recognized. This review summarizes current research progress on exosomes in sicca syndrome, glaucoma, age.related macular degeneration, diabetic retinopathy and uveal melanoma, with a focus on their applications as diagnostic biomarkers and therapeutic delivery vehicles.

keywords: Exosomes Sicca syndrome Glaucoma Age.related macular degeneration Diabetic retinopathy

文章编号： 中图分类号：R771 文献标志码：A

基金项目:国家自然科学基金面上项目（82274447）；北京市自然科学基金（7212172）；北京市高层次公共卫生技术人才建设资助项目（2022-2-024）；北京市属医学科研院所公益发展改革试点项目（2019-6，2021-10）；内蒙古自治区人才开发基金高层次人才个人项目；首都卫生发展科研专项（2024-2-1152）

引用文本：

Author Name	Affiliation
SHEN Wenqing	Capital Medical University, Beijing 100069, China
XU Fang	Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medicine University, Beijing 100069, China
LUO Shumin	Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medicine University, Beijing 100069, China
LU Pengpeng	Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medicine University, Beijing 100069, China
CAI Chao	The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 0100301, China
LI Weihua	Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medicine University, Beijing 100069, China

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