Abstract:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, characterized by anovulation, hyperandrogenemia, and ovarian polycystic changes. It affects the fertility and health of patients. In recent years, the gut microbiota has been recognized as an endocrine organ in the human body, playing a role in metabolism, immunity, and reproduction. In PCOS patients, there is an imbalance in the gut microbiota and dysfunction of the intestinal barrier. Furthermore, the gut microbiota is also regulated bidirectionally by the brain, which may suggest that the microbiota-gut-brain axis is related to the onset and development of PCOS. Chinese Medicine considers the occurrence of PCOS to be closely related to the liver, spleen, and kidneys, and treatment can target gut microbiota, insulin resistance, and hyperandrogenism, with fewer side effects and good clinical efficacy. This article reviews the role of the microbiota-gut-brain axis in PCOS and the progress of Chinese Medicine interventions.