Abstract:Receptor agonists developed based on intestinal hormones have been proven to be one of the effective means for treating obesity and type 2 diabetes, with promising application prospects. Their therapeutic mechanisms involve regulating energy balance and improving pancreatic function, among other aspects. Intestinal hormones, as important substances for regulating energy balance, play a regulatory role in body weight and glucostasis through different signaling pathways in various tissues, indicating that intestinal hormones have complex regulatory mechanisms in the development of obesity and type 2 diabetes. Therefore, research on intestinal hormones as treatment targets for obesity and type 2 diabetes has attracted widespread attention. This article summarizes the current mechanism of action of intestinal hormones and related treatment plans, providing ideas for the development of intestinal hormone receptor agonists.