Abstract:Sepsis refers to life-threatening organ dysfunction caused by a host's dysregulated response to an infection, while septic shock is characterized by severe circulatory, cellular, and metabolic dysfunction in combination with sepsis. Disruption of coagulation function is a key factor in the pathophysiological process of septic shock. Thrombelastography (TEG) is an indicator that reflects the dynamic changes in blood coagulation. Compared to conventional coagulation tests, TEG has the advantages of shorter measurement time, minimal blood usage, and no interference from heparin. Patients with septic shock often have a poor prognosis, with activation of the coagulation system and interaction with the inflammatory response. TEG parameters are closely related to inflammatory markers in septic shock patients. This article describes changes in coagulation function in patients with septic shock, the relationship between TEG parameters and inflammatory markers in septic shock patients, summarizes the application of TEG in guiding the treatment of septic shock, discusses the advantages and limitations of TEG in evaluating septic shock, and seeks more ways to identify septic shock patients early and improve patient outcome.