Abstract:The pathogenesis of sepsis is complex. The early stage of sepsis is accompanied by the emergence of pro-inflammatory-anti-inflammatory mechanisms, which can lead to excessive inflammation and immunosuppression, and even long-term immune disorders. With the in-depth study of sepsis, more and more evidence show that immunosuppression is an important feature of sepsis. Although evidence of immunosuppression in patients with sepsis is increasing, the research on how sepsis affects the body‘s immune function and the effects of sepsis‘s immunosuppression on immune cells is still in its infancy. This review focuses on the recent research on the pathogenesis of sepsis and provides a theoretical basis for its clinical prevention and treatment.