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Received:September 14, 2022 Published Online:May 20, 2023
Received:September 14, 2022 Published Online:May 20, 2023
中文摘要: 风湿免疫性疾病包括系统性红斑狼疮（SLE）、类风湿性关节炎（RA）、干燥综合征（SS）、系统性血管炎、强直性脊柱炎（AS）以及IgG4相关性疾病（IgG4RD）等。自身抗体的形成是多数风湿免疫性疾病发生发展的基础,这些自身抗体主要来源于位于次级淋巴器官的生发中心（GC）中的B细胞,而滤泡辅助性T细胞（Tfh）在GC B细胞的活化、增殖和分化成熟过程中起着关键作用。近年来相关研究发现,多种风湿免疫病的发病与Tfh异常相关,而其中一组亚群（Tfh17）同多种风湿免疫病的发生发展有着密切关系。本文对Tfh17在风湿免疫病中的最新研究进展作一综述。
中文关键词: 滤泡辅助性T细胞 系统性红斑狼疮 类风湿性关节炎 干燥综合征 IgG4相关性疾病
Abstract:Rheumatic diseases include systemic lupus erythematosus（SLE）, rheumatoid arthritis（RA）, Sjgren‘s syndrome（SS）, systemic vasculitis, ankylosing spondylitis（AS） and IgG4-related diseases（IgG4RD）. The formation of autoantibodies is the basis for the development of most rheumatic diseases, which are mainly derived from B cells located in the germinal center（GC） of secondary lymphoid organs, while follicular helper T cells（Tfh） play the key role in the activation, proliferation, differentiation and maturation of GC B-cells. In recent years, the relevant studies have found that the development of a variety of rheumatic diseases is associated with abnormal distribution of Tfh, especially the Tfh17 subset. This article reviews the latest research progress of Tfh17 in rheumatic immune diseases.
keywords: Follicular helper T cells Systemic lupus erythematosus Rheumatoid arthritis Sjgren‘s syndrome IgG4-related diseases
文章编号： 中图分类号：R593.2 文献标志码：A
基金项目:南京市卫生青年人才培养工程第二层次（QRX17064）
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