Abstract:The pathogenesis and therapeutic targets of neuroinflammation in Alzheimer‘s disease（AD） are hot research topics. β-adrenergic receptors（β-AR） can regulate neuroinflammation during the pathogenesis of AD. β-AR is expressed in innate immune cells（microglia and astrocytes） of the central nervous system, blood brain barrier, and peripheral immune cells, which can stimulate the expression of AR in these cells and structures to suppress neuroinflammation. The review describes the role of β-AR in neuroinflammation in AD, and summarizes the studies of β-AR agonists and blockers in neuroinflammation, aiming to provide a new idea for pathogenesis and therapeutic target research of AD in future.