Abstract:Helicobacter pylori is one kind of common pathogenic bacteria in the human stomach, which can not only cause organic damage to the digestive system, but also participate in the occurrence and development of various gastrointestinal motility disorders. Helicobacter pylori affects gastrointestinal motility through a variety of mechanisms. It can have direct effects on gastrointestinal motility, such as affecting the secretion of gastrointestinal hormones and neuropeptides, reducing Cajal interstitial cells, developing low-grade inflammation. It can also have indirect effects on gastrointestinal motility through microbiome-brain-gut axis, neuroimmune mechanisms and neuroendocrine mechanisms. Therefore, the eradicative treatment of Helicobacter pylori can also have a beneficial impact on gastrointestinal motility. It can benefit most patients with gastrointestinal organic diseases and functional gastrointestinal disease.