Abstract:Investigators as clinical trials specific actors, are the key to quality assurance of clinical trials, and their enthusiasm and involvement are one of the factors affecting the quality of clinical research. Guided by Maslows hierarchy of needs theory, this paper analyze the needs of clinical trial investigators, formulate a researcher management mechanism, which includes labor distribution system, supporting guarantee mechanism, good communication mechanism, scientific evaluation system, professional training system, in order to improve the quality and level of clinical trials.