Abstract:Objective To explore the effect of Yupingfeng Granule combined with Xuanfei Decoction on inflammatory response in children with bronchial asthma. Methods A total of 100 children with bronchial asthma treated in the outpatient department of Zhangjiakou Infectious Disease Hospital from January 2020 to January 2021 were selected retrospectively, and divided into combination group and control group（n=50, each） according to different treatment methods. Based on routine treatment in both groups, Xuanfei Decoction was given in control group, and Yupingfeng Granules (treatment course of one week） and Xuanfei Decoction were given in combination group, and the treatment course of Xuanfei Decoction were 2 months in both groups. The levels of interferon-γ（INF-γ）, interleukin（IL）-4 and IL-13 were detected to observe the changes of lung function and immune function before and after treatment and to compare the treatment effect and safety between two groups. Results Before treatment, there were no significant differences in the levels of INF-γ, IL-4, IL-13, forced expiratory volume in the first second（FEV1）, percentage of FEV1 to forced vital capacity（FEV1/FVC）, peak expiratory flow am（PEFam） in both groups and peak expiratory flow pm（PEFpm）（P＞0.05）. After treatment, IL-4 and IL-13 levels decreased, and INF-γ, FEV1, PEFam, FEV1/FVC and PEFpm increased significantly compared with those before treatment in both groups. After treatment, the levels of IL-4 and IL-13 in the combination group were statistically lower than those in control group, and the levels of INF-γ, FEV1, PEFam, FEV1/FVC and PEFpm were higher than those in control group（P＜0.05）. Compared with those in control group,the clinical symptom improvement time or disappearance time significantly decreased, with higher treatment efficiency in combination group（P＜0.01）. Conclusion Yupingfeng Granules combined with Xuanfei Decoction can reduce inflammation, improve treatment efficiency and clinical symptoms and promote the recovery of children with bronchial asthma.