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Received:December 12, 2021 Published Online:June 20, 2022
Received:December 12, 2021 Published Online:June 20, 2022
中文摘要: T细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域 (TIGIT)是一种新的免疫检查点受体，是主要表达于T细胞和自然杀伤细胞（NK细胞）表面的一种免疫抑制性受体，通过抑制T细胞和NK细胞介导的免疫反应影响肿瘤微环境，促进肿瘤的发生发展。本文介绍TIGIT分子的结构与功能，并对TIGIT分子在血液淋巴系统恶性肿瘤的免疫调控、应用和前景作一综述。
Abstract:T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) is a novel type of immune checkpoint receptor and an immunosuppressive receptor mainly expressed on the cell surface of T cells and NK cells. TIGIT affects the tumor microenvironment and promotes the occurrence and development of tumor by inhibiting the immune response mediated by T cells and NK cells. This paper introduces the structure and function of TIGIT molecule and reviews its immune regulation, application and prospect in hematological malignancies.
keywords: T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain Immunomodulatory Hematological malignancies Immune checkpoint blocker
文章编号： 中图分类号：R733 文献标志码：A
基金项目:
| Author Name | Affiliation |
| WANG Yue-na, LIU Jia, LI Li-juan, ZHANG Lian-sheng | Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China |
| Author Name | Affiliation |
| WANG Yue-na, LIU Jia, LI Li-juan, ZHANG Lian-sheng | Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China |
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