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Received:March 07, 2022 Published Online:June 20, 2022
Received:March 07, 2022 Published Online:June 20, 2022
中文摘要: 食管鳞状细胞癌（ESCC）为食管癌主要病理分型，是由食管鳞状上皮异型增生所致，具有发病率高、死亡率高等特点。除肿瘤自身特性外，ESCC的进展还与肿瘤所在的微环境密切相关。肿瘤相关巨噬细胞（TAMs）为肿瘤组织浸润的重要免疫细胞，其在不同微环境刺激下可呈现不同性质活化状态，主要分为经典活化的巨噬细胞（M1型巨噬细胞）和替代性活化的巨噬细胞（M2型巨噬细胞），其中，M2型巨噬细胞相对更多。本文就TAMs对ESCC生物学行为的影响、疾病预后判断价值进行综述。
Abstract:Esophageal squamous cell carcinoma (ESCC) is the main pathological type of esophageal cancer. It is caused by esophageal squamous dysplasia. It has high incidence rate and high mortality. In addition to the characteristics of the tumor itself, the progress of ESCC is also closely related to the microenvironment of the tumor. Tumor associated macrophages (TAMs) are important immune cells infiltrated by tumor tissue. They can show different activated states under different microenvironment stimuli. They are mainly divided into classical activated macrophages (M1 macrophages) and alternative activated macrophages (M2 macrophages). Among them, M2 macrophages are relatively more.This paper reviews the influence of TAMs on the biological behavior of ESCC and the value of judging the prognosis of the disease.
keywords: Tumor associated macrophages Esophageal squamous cell carcinoma Subtype M1 macrophages M2 macrophage
文章编号： 中图分类号：R735.1 文献标志码：A
基金项目:江苏省“333高层次人才工程”科研项目（BRA2017121）
| Author Name | Affiliation |
| WANG En-jing, HUANG Jin | Department of Gastroenterology, Changzhou No.2 People’s Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, China |
| Author Name | Affiliation |
| WANG En-jing, HUANG Jin | Department of Gastroenterology, Changzhou No.2 People’s Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, China |
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