Abstract:In recent years, great progress has been made in the treatment of bladder cancer, including traditional surgical resection, chemotherapy and radiotherapy and immunotherapy. However, its potential molecular mechanisms and key pathways remain unclear. With the progress of sequencing gene technology, long non-coding RNA （lncRNA） has been proved to show the role of oncogenes in a variety of tumor tissues by different molecular mechanisms. The competing endogenous RNA （ceRNA） hypothesis is a new mechanism of interaction between RNAs. As competing for miRNA binding sites with endogenous miRNAs, lncRNA can be regarded as a sponge to adsorb miRNA, leading to relieve the inhibition of miRNA on its target gene and increase the expression level of target gene. This article reviews the latest research progress on the involvement of lncRNA as ceRNA in the progression of bladder cancer.