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Received:October 18, 2021 Published Online:April 20, 2022
Received:October 18, 2021 Published Online:April 20, 2022
中文摘要: 异相睡眠剥夺（PSD）与术后疼痛的发生密切相关，其机制尚未明确。近年来研究发现，脑源性神经营养因子(BDNF)是PSD的重要调节因子。BDNF/酪氨酸激酶受体B(TrkB) 信号通路在PSD致术后痛觉敏化中的作用也被逐渐认识，本文对BDNF/TrkB通路参与PSD致术后痛觉敏化的相关研究现状做一综述，以期为PSD致术后痛觉敏化的临床预防及治疗提供新方向。
中文关键词: 脑源性神经营养因子/酪氨酸激酶受体B信号通路 术后疼痛 异相睡眠剥夺 痛觉敏化
Abstract:Paradoxical sleep deprivation is closely related to postoperative pain. However, its underlying mechanism is unclear. In recent years, studies have found brain-derived neurotrophic factor (BDNF) is an important regulator of PSD, and the role of BDNF/ tyrosine kinase receptor B (TrkB) signaling pathway in postoperative pain sensitization after PSD has also been gradually recognized. This article will review the related research progress of BDNF/TrkB signaling pathway involved in PSD-induced postoperative pain sensitization, in order to provide a new direction for the clinical prevention and treatment of postoperative pain sensitization caused by PSD.
keywords: Brain-derived neurotrophic factor/tyrosine kinase receptor B signaling pathway Postoperative pain Paradoxical sleep deprivation Pain sensitization
文章编号： 中图分类号：R619 文献标志码：A
基金项目:甘肃省自然科学基金项目（21JR7RA586）；甘肃省科技计划项目（20JR10RA435）
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