Abstract:Type 2 diabetes mellitus (T2DM, accounted for more than 90% of the total number of diabetic patients) is the third most common disease after cancer and cardiovascular disease. In recent years, it has been found that bile acids play an important role in glucose homeostasis through farnesoid X receptor (FXR). This review focuses on the enterohepatic circulation of bile acid, the mechanism of bile acid regulating glucose metabolism and insulin secretion in different organs through FXR pathway and on the relationship between FXR and T2DM in order to provide new ideas for the exploration of the pathogenesis and treatment of T2DM.