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Received:July 23, 2021 Published Online:March 20, 2022
Received:July 23, 2021 Published Online:March 20, 2022
中文摘要: 类风湿关节炎（RA）是一种常见的慢性炎症性自身免疫疾病，有高致残率和死亡率，而肥胖增加患RA的风险，但其发病机制和病因尚不明确，给治疗带来很大困难。辅助性T细胞（Th）17和调节性T细胞（Treg）由一个共同的前体细胞(幼稚的CD4+T细胞)发育而来，它们是两个功能相反的淋巴细胞亚群，Th17/Treg平衡在RA的发生和发病机制中发挥重要作用。肥胖人群中脂肪组织积累可改变T细胞数量和功能，Th17细胞数量增多、功能亢进，Treg细胞数量减少、功能低下，加重了RA病程的发展。研究Th17/Treg失衡与肥胖人群中RA患病率升高的相关性，对RA的发病机制及诊治的研究具有重要价值。
中文关键词: 类风湿关节炎 肥胖 辅助性T细胞 调节性T细胞 Th17/Treg平衡
Abstract:Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease with high disability and mortality. It has been widely publicized that obesity increases the risk of RA, but unclear pathogenesis and etiology of RA brings great difficulties to treatment. Helper T（Th） cells and regulatory T cells(Treg) are developed from a common precursor cell (naive CD4+T cells). They are two subgroups of lymphocytes with opposite functions. Th17/Treg balance plays an important role in the occurrence and pathogenesis of RA. The accumulation of adipose tissue in obese people can change the number and function of T cells. The increased qunantity and hyperfunction of Th17 cells with the reduced number and function of Treg cells aggravates the development of RA. The study of the correlation between Th17/Treg imbalance and the increased prevalence of RA in obese people is of great value in exploring the pathogenesis, diagnosis and treatment of RA.
文章编号： 中图分类号：R593.22 文献标志码：A
基金项目:
| Author Name | Affiliation |
| CHEN Li, LI Fang, WEN Li-na, DUAN Rui | Department of Rheumatology and Immunology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China |
| Author Name | Affiliation |
| CHEN Li, LI Fang, WEN Li-na, DUAN Rui | Department of Rheumatology and Immunology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China |
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