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中国临床研究英文版:2020,33(8):1090-1093
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玻璃酸钠滴眼液联合睑板腺疏通治疗儿童中度干眼症的效果
(秦皇岛市第二医院眼科,河北 秦皇岛066000)
Effect of sodium hyaluronic ophthalmic solution combined with meibomian gland dredge on children with moderate dry eyes
(Department of Ophthalmology,Qinhuangdao Second Hospital,Qinhuangdao,Hebei 066000,China)
摘要
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Received:December 04, 2019   Published Online:August 20, 2020
中文摘要: 目的 探讨玻璃酸钠滴眼液联合睑板腺疏通治疗儿童中度干眼症的临床疗效及安全性。方法 选择2014年1月至2018年12月收治的128例中度干眼症并伴有睑板腺异常的患儿为研究对象,按照随机数字表法分为联合组与对照组(各64例)。对照组单纯应用玻璃酸钠滴眼液治疗,联合组进行玻璃酸钠滴眼液联合睑板腺疏通治疗。比较两组患儿临床疗效、不良反应发生情况及治疗前后泪膜破裂时间(BUT)、基础泪液分泌试验(SIT)、眼表疾病指数(OSDI)、睑板腺、角膜荧光素染色(FLS)评分。结果 联合组患儿临床治疗效果总有效率高于对照组(95.31% vs 84.38%,P<0.05)。治疗后,两组患儿OSDI评分均降低,BUT、SIT升高(P<0.05),且联合组OSDI评分低于对照组,BUT、SIT均高于对照组(P<0.01)。治疗后,联合组与对照组睑板腺、FLS评分降低,且联合组睑板腺、FLS评分低于对照组(P<0.05,P<0.01)。联合组与对照组患儿不良反应发生率比较无统计学差异(3.13% vs 6.25%,P>0.05)。结论 玻璃酸钠滴眼液联合睑板腺疏通治疗中度干眼症患儿的临床疗效优于单纯应用玻璃酸钠滴眼液治疗,且能够有效减轻患儿的临床症状,安全可靠。
Abstract:ObjectiveTo compare the clinical efficacy and safety of sodium hyaluronate eyedrops combined with meibomian gland dredging and sodium hyaluronate eyedrops alone in the treatment of children with moderate dry eye.MethodsA total of 128 children with moderate dry eye and meibomian gland disfunction treated from January 2014 to December 2018 were selected and randomly divided into the combined group in which sodium hyaluronic ophthalmic solution combined with meibomian gland dredge was performed and the control group in which sodium hyaluronate eye drops alone was given(n=64,each).The clinical efficacy,adverse reactions,tear film break-up time (BUT),basic tear secretion test (SIT),ocular surface disease index (OSDI),meibomian gland score(MGS)and corneal fluorescein staining (CFS) were compared between two groups.ResultsThe total effective rate in combined group was significantly higher than that in control group (95.31% vs 84.38%,P<0.05).After treatment,the scores of OSDI decreased,and BUT and SIT increased in two groups(P<0.05);compared with control group,OSDI decreased,and BUT and SIT increased statistically in combined group(P<0.01).After treatment,the scores of meibomian gland and corneal fluorescein decreased in both groups and were significantly lower in combined group than those in control group(P<0.05,P<0.01).There was no significant difference in the incidence of adverse reactions between combination group and control group (3.13% vs 6.25%,P>0.05).ConclusionIn the treatment of children with moderate dry eye,sodium hyaluronate eye drops combined with meibomian gland dredge has better clinical efficacy compared with sodium hyaluronate eye drops alone and can effectively reduce the clinical symptoms of children with less adverse reactions.
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