Abstract:Objective To investigate the application effect of Lidan Paishi granule combined with ursodeoxycholic acid capsule in patients with calculus of intrahepatic duct after laparoscopy,and its mid-term follow-up result. Methods A total of 96 patients with calculus of intrahepatic duct who received laparoscopy from June 2013 to June 2015 were selected and divided into observation group and control group according to the drawing lots method (n=48,each).The control group was treated with ursodeoxycholic acid capsule after operation,while the observation group was treated with Lidan Paishi granule combined with ursodeoxycholic acid capsule after operation.All patients were treated for 3 months.The treatment effect and incidence of adverse reactions in the two groups were counted,and the improvement of symptoms and related bile indicators ［total bile acid (TBA),phospholipid (PLIP),cholesterol (CHO)］ levels before and after treatment in the two groups were compared. Results After 3 months of treatment,the treatment effect of observation group was significantly better than that of control group (P<0.05).Compared with the control group,the right upper abdominal pain,jaundice and chills fever rate decreased,the levels of TBA and PLIP in bile increased,and the levels of CHO decreased in the observation group (all P<0.05).The incidence of adverse reactions in the observation group was slightly higher than that in the control group,and there was no significant difference between the two groups (8.33% vs 6.25%,P＞0.05). Conclusion Lidan Paishi granule combined with ursodeoxycholic acid capsule has a definite therapeutic effect in patients with calculus of intrahepatic duct after laparoscopy.It can significantly alleviate the clinical symptoms,improve the levels of TBA,PLIP and CHO in bile,inhibit the formation of stones,reduce the residual and recurrence of stones,and has a high safety.