Abstract:Objective To investigate the clinical effect of Huanglian Jiedu decoction combined with carvedilol in the treatment of unstable angina pectoris (UAP)with fire-evil and heat-knot syndrome and its influence on life quality. Methods A total of 60 UAP patients who received treatment from December 2015 to December 2016 were selected and divided into observation group and control group according to the drawing lots method (n=30,each).The control group was treated with carvedilol,while the observation group was treated with Huanglian Jiedu decoction combined with carvedilol.All patients were treated for 3 months.The ECG efficacy,clinical efficacy and incidence of adverse reactions of the two groups were counted.The frequency and duration of angina pectoris attack,the level of serum matrix metalloproteinase-9 (MMP-9),vascular endothelial growth factor (VEGF) and the quality of life score (SF-36) before and after treatment were compared between the two groups. Results After treatment,the curative effect and clinical effect of ECG in the observation group were significantly better than those in the control group (all P<0.05).After the treatment,the angina frequency,angina duration and the level MMP-9 and VEGF in both groups were lower than those before treatment,and these in the observation group were lower than those in control group (all P<0.01).The SF-36 scores of the two groups were higher 6 months after treatment than before,and the observation group was higher than the control group (all P<0.01).There was no significant difference in incidence of adverse reaction between observation group and control group ［13.33 %(4/30) vs 10.00 %(3/30),P>0.05］. Conclusion Huanglian Jiedu decoction combined with carvedilol is effective in UAP patients with fire-evil heat-knot syndrome.It can significantly reduce the level of serum MMP-9 and VEGF,reduce the frequency and duration of angina attack,and improve the quality of life of patients with high safety.