Abstract:Endometrial cancer is one of the three major malignant tumors in the female reproductive system, with the incidence and mortality rates increasing globally. Early-stage endometrial cancer patients have a good prognosis, but the 5-year survival rate for advanced and recurrent endometrial cancer is less than 40%. In recent years, the combined use of immunotherapy and molecular targeted therapy with traditional chemotherapy has significantly improved the survival of these patients. However, when targeted drugs or immune checkpoint inhibitors are used alone, the objective response rate of the tumors is not significantly improved. Therefore, it is crucial to seek more efficient treatment targets for advanced and recurrent endometrial cancer. Tumor metabolism reprogramming has attracted attention due to its ability to change the metabolic patterns of tumor cells to meet their energy needs for proliferation and growth. Previous studies on metabolic changes in endometrial cancer have mainly focused on carbohydrate metabolism, but existing research suggests that changes in fatty acid metabolism also play an important role. Fatty acid metabolism reprogramming includes imbalances in fatty acid synthesis, uptake, and oxidation. Abnormal expression of enzyme protein key factors catalyzing related reactions in the metabolic process is the key to the imbalance of fatty acid metabolism. Therefore, exploring the changes in fatty acid metabolism and the role and changes of key factors such as fatty acid metabolism-related enzyme proteins in the fatty acid metabolism pathway plays an important role in finding new treatment methods and potential efficient treatment targets for endometrial cancer.