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投稿时间:2023-12-09 网络发布日期:2024-11-20
投稿时间:2023-12-09 网络发布日期:2024-11-20
中文摘要: 门静脉高压(PH)是多种原因导致门静脉血流受阻和(或)血流量增加的结果,也是肝硬化失代偿期的直接原因,可在短期内升高患者死亡率。因此,早发现、早治疗及早监测PH对改善患者预后、降低死亡率具有重要意义。无创预测模型具有安全、简便、经济的特点,在PH的评估中有重要价值,是近年来的研究热点。本文综述了肝功能测定评分(Child-Pugh评分)、天冬氨酸转氨酶/血小板比值指数评分(APRI评分)、整合的终末期肝病模型评分(iMELD评分)、增强的肝纤维化评分(ELF)、肝硬度×脾脏直径/血小板计数评分(LSPS)、血管性血友病因子抗原/血小板计数评分(VITRO评分)六项无创预测模型在肝硬化PH诊断及预后评估中的研究进展。
Abstract:Portal hypertension (PH) is the result of portal blood flow obstruction and/or increased blood flow caused by various reasons, and is also the direct cause of decompensation of cirrhosis, which can increase the mortality of patients in a short time. Therefore, early detection, early treatment and early monitoring of PH have great significance to improve the prognosis of patients and reduce the mortality. Noninvasive prediction model has the characteristics of safety, simplicity and economy, and has important value in PH evaluation, which is a research hotspot in recent years. In this review, six noninvasive prediction models, including liver function test score (Child-Pugh score), aspartate aminotransferase/platelet ratio index score (APRI score), integrated end-stage liver disease model score (iMELD score), enhanced liver fibrosis score, liver hardness spleen diameter/platelet count score (LSPS), von lebrand factor antigen/platelet count score (VITRO score), were reviewed for PH diagnosis and prognosis assessment of cirrhosis.
文章编号: 中图分类号:R575.2 文献标志码:A
基金项目:湖北省卫生健康委员会面上项目(WJ2019M257);武汉市卫生健康委员会指导项目(WX21Z30)
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引用文本:
杨丹,周健.多种无创预测模型在肝硬化门静脉高压中的研究进展[J].中国临床研究,2024,37(11):1778-1783.
杨丹,周健.多种无创预测模型在肝硬化门静脉高压中的研究进展[J].中国临床研究,2024,37(11):1778-1783.