Abstract:Objective To study the feasibility of sentinel lymph node (SLN) mapping during pelvic lymphadenectomy of women with high-risk endometrial cancer.Methods SLN mapping was performed in 79 patients with high-risk endometrial carcinoma (poorly differentiated endometrial adenocarcinoma,serous carcinoma,clear cell carcinoma and carcinosarcoma),who underwent laparoscopic total hysterectomy,pelvic and para-aortic lymphadenectomy plus bilateral adnexectomy from January 2015 to August 2019.The accuracy,sensitivity and specificity of SLN localization,postoperative adjuvant therapy and tumor recurrence were analyzed.Results Of 14 patients with pelvic lymph node metastasis confirmed by pathological examination,13 cases showed metastasis in SLN.The accuracy,specificity and sensitivity of SLN mapping were 92.8%(13/14),98.48%(65/66） and 100%(13/13),respectively．Out of 15 patients with recurrence during 15 months after operation,there were 6 patients with pelvic lymph node recurrence,which were consistent with the intraoperative SLN analysis.ConclusionIn the patients with high-risk endometrial cancer during operation,detection of sentinel lymph node metastases is feasible,but more research with large sample size is needed to determine whether lymphadenectomy with SLN mapping can safely replace systemic lymphadenectomy.