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投稿时间：2020-04-02 网络发布日期：2020-11-20
投稿时间：2020-04-02 网络发布日期：2020-11-20
中文摘要: 目的 研究益肾健脾方对脾肾亏虚型肿瘤相关乏力的治疗效果。方法 选择2018年10月至2019年3月收治的60例肿瘤相关性乏力患者,随机分为试验组和对照组,两组各脱落1例,试验组29例和对照组29例进行研究。试验组以益肾健脾方作为基本治法,对照组采用营养支持等对症治疗,疗程为2周。观察比较两组乏力［简明疲劳量表中文版(BFI-C)］、睡眠［匹斯堡睡眠指数量表(PSQI)］、抑郁［医院焦虑抑郁量表(HADS)］及中医症候积分改善情况。结果 试验组乏力的治疗有效率(48.28% vs 10.34%,χ2=8.290,P=0.004)、中医证候治疗总有效率(65.51% vs 31.03%,χ2=6.905,P=0.009)高于对照组,差异有统计学意义。治疗2周后,试验组BFI-C评分较治疗前改善,且试验组低于对照组(P<0.05)。而两组握力、抑郁、睡眠质量评分在治疗前后比较无统计学差异(P>0.05)。结论 益肾健脾方治疗肿瘤相关性乏力有一定疗效,可为临床治疗提供参考。
Abstract:Objective To investigate the clinical effect of Yishen Jianpi decoction on tumor related asthenia of spleen and kidney deficiency syndrome.Methods A total of 60 patients with tumor related fatigue admitted from October 2018 to March 2019 were divided into experimental group and control group randomly ( n=30,each).The experimental group was treated with Yishen Jianpi decoction,while the control group was treated with nutritional support.All the patients received treatment for 2 weeks.The improvement of fatigue (BFI-C),sleep (PSQI),depression (HADS) and Traditional Chinese Medicine(TCM) symptom score were observed and compared between the two groups.Results The effective rate of fatigue treatment in the experimental group was higher than that in the control group (48.28% vs 10.34%, χ2=8.290, P=0.004).The total effective rate of TCM syndrome in the experimental group was higher than that in the control group (65.51% vs 31.03%, χ2=6.905, P=0.009).After 2 weeks of treatment,the BFI-C score of the experimental group was improved compared with that before treatment,and the BFI-C score of the experimental group was lower than that of the control group ( P<0.05).There was no significant difference in grip strength,depression and sleep quality between the two groups before and after treatment ( P>0.05).Conclusion Yishen Jianpi decoction has a certain effect on tumor related asthenia.
keywords: Yishen Jianpi decoction Spleen and kidney deficiency syndrome Tumor related fatigue Concise fatigue scale Traditional Chinese Medicine syndrome
文章编号： 中图分类号： 文献标志码：B
基金项目:
| Author Name | Affiliation |
| REN Run-hua*,LI Jian-yue | *Department of Geriatric Medicine,the Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing,Jiangsu 210000,China |
引用文本：
任润华,李检阅.益肾健脾方对脾肾亏虚型肿瘤相关性乏力的疗效[J].中国临床研究,2020,33(11):1540-1543.
任润华,李检阅.益肾健脾方对脾肾亏虚型肿瘤相关性乏力的疗效[J].中国临床研究,2020,33(11):1540-1543.