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投稿时间：2020-07-02 网络发布日期：2020-11-20
投稿时间：2020-07-02 网络发布日期：2020-11-20
中文摘要: 目的 探讨补肾活血方治疗糖尿病性骨质疏松(DOP)的临床效果。方法 选取2017年1月至2020年 1月在中医科、内分泌科门诊及住院的DOP患者55例,随机分为对照组(n=27)及治疗组(n=28)。对照组在控制其他原发病基础上加用碳酸钙D3 600 mg+骨化三醇胶丸0.5 μg,治疗组在对照组基础上加用补肾活血方,治疗周期为6个月。观察并比较两组治疗前后VAS评分、肝功能［丙氨酸氨基转移酶(ALT)、谷氨酸氨基转移酶(AST)］、骨代谢指标［I型胶原氨基端延长肽(P1NP)、β-I型胶原羧基端肽(β-CTX)］、骨密度(腰椎L1~4及左侧股骨)。结果 与对照组相比,治疗后治疗组VAS评分、β-CTX水平降低,P1NP水平升高,腰椎(L1~4)及左侧股骨骨密度增加,差异有统计学意义(P<0.05,P<0.01)。两组治疗前后肝功能指标比较差异无统计学意义(P>0.05)。结论 补肾活血方可有效缓解DOP患者疼痛,改善骨代谢,增加骨密度,且无明显肝损作用。
Abstract:Objective To investigate the clinical effect of Bushen Huoxue decoction on diabetic osteoporosis (DOP).Methods A total of 55 outpatients or inpatients with DOP who received treatment in the Department of TCM or Endocrinology from January 2017 to January 2020 were randomly divided into control group ( n=27) and treatment group ( n=28).The control group was treated with calcium carbonate and vitamin D3 tablets 600 mg+calcitriol capsules 0.5 μg on the basis of controlling other primary diseases,and the treatment group was added with Bushen Huoxue decoction on the basis of control group.The treatment period was 6 months.The VAS score,liver function ［alanine aminotransferase (ALT),glutamate aminotransferase (AST)］,bone metabolism index ［type I collagen N-terminal lengthening peptide (P1NP),β-I collagen carboxyl terminal peptide (β-CTX)］,bone mineral density (BMD) were observed and compared between the two groups before and after treatment.Results Compared with the control group,the VAS score and β-CTX level in the treatment group were decreased,the P1NP level,BMD of lumbar spine (L1-4) and left femur was increased ( P<0.05).There was no significant difference in liver function between the two groups before and after treatment ( P>0.05).Conclusion Bushen Huoxue decoction could relieve pain,improve bone metabolism and increase bone mineral density in patients with DOP without obvious liver damage,which can be used in clinical treatment of DOP.
文章编号： 中图分类号： 文献标志码：B
基金项目:南京大学医院管理研究所课题研究项目(NDYG2019026)
| 作者 | 单位 |
| 房其军1 | 1.南京大学医学院附属鼓楼医院中医科,江苏 南京 210008； |
| 杨海明1 | 1.南京大学医学院附属鼓楼医院中医科,江苏 南京 210008； |
| 刘莹露1 | 1.南京大学医学院附属鼓楼医院中医科,江苏 南京 210008； |
| 吴薇1 | 1.南京大学医学院附属鼓楼医院中医科,江苏 南京 210008； |
| 沈山梅2 | 2.南京大学医学院附属鼓楼医院内分泌科,江苏 南京 210008 |
引用文本：
房其军,杨海明,刘莹露,等.补肾活血方治疗2型糖尿病性骨质疏松的疗效观察[J].中国临床研究,2020,33(11):1537-1539.
房其军,杨海明,刘莹露,等.补肾活血方治疗2型糖尿病性骨质疏松的疗效观察[J].中国临床研究,2020,33(11):1537-1539.