Abstract:Objective T o explore the changes and significance of serum interleukin (IL)-6,C-reactive protein (CRP) and homocysteine (Hcy) in obese patients with diabetic ketoacidosis (DKA).Methods Fifty patients who were hospitalized in the department of endocrinology and were diagnosed with DKA from September 2018 to May 2019 were collected as the research objects.At the same time,25 healthy subjects were selected as the control group.According to the body mass index (BMI),the DKA patients were divided into obese DKA group (BMI≥25 kg/m2, n=25) and non-obese DKA group (BMI<25 kg/m2, n=25).OPTI blood gas analyzer was used to analyze arterial blood gas(pH,HCO3-),Luminex200 was used to detect IL-6 levels,AU2700 was used to detect Hcy and serum glucose levels,and BNProSpec specific protein analyzer was used to detect CRP levels.Results Compared with the time of admission,the serum glucose of obese and non-obese DKA patients were significantly reduced after insulin treatment for 24 hours,and the pH and HCO3- were significantly increased ( P<0.01).Compared with the control group,the serum IL-6,CRP and Hcy levels of obese and non-obese DKA patients were significantly increased upon admission ( P<0.05).Compared with the time of admission,the levels of IL-6,CRP and Hcy in obese and non-obese DKA patients were significantly lower after 24 hours of insulin treatment ( P<0.01),but the levels of IL-6,CRP and Hcy in obese DKA patients were still high than those of the control group ( P<0.05).ConclusionThe levels of serum IL-6,CRP and Hcy in obese DKA patients play an important role in the disease process.