Abstract:ObjectiveTo investigate the effects of different treatment modes on the prognosis of patients with esophageal squamous cell carcinoma(ESCC). Methods A retrospective analysis was made on 367 ESCC patients treated from January 2010 to December 2015.The survival time of 347 patients was counted through outpatients and telephone follow-up.The prognostic factors such as gender,age,treatment mode,lesion location,differentiation degree,lesion length,vascular tumor thrombus,nerve invasion,TNM stage were collected,and the influencing factors of survival rate changes were analyzed by Cox regression analysis and Kaplan-Meier method. Results Univariate analysis showed that the 3-year survival rates were 51.9%,73.9%,74.5%,61.6% in surgery alone group,surgery plus chemotherapy group,surgery plus radiotherapy group,surgery plus radiotherapy and chemotherapy group,respectively.The 3-year survival rate of simple surgery group was significantly lower than those of comprehensive treatment groups (P<0.05).Cox regression multivariate analysis showed that treatment mode and TNM staging were the independent influencing factors of prognosis in patients with esophageal cancer (P<0.05). Conclusion Comprehensive treatment is recommended for patients with esophageal cancer,and treatment mode and TNM staging are the independent influencing factors of patient′s survival.