Abstract:ObjectiveTo explore the clinical efficacy of neoadjuvant chemotherapy(NACT) combined with totally laparoscopic distal gastrectomy with D2 lymphadenectomy. Methods A total of 72 patients undergoing radical distal gastrectomy from January 2015 to June 2017 were enrolled and divided into observation group (n=33) in which totally laparoscopic distal gastrectomy was performed after neoadjuvant chemotherapy with SOX regimen (oxaliplatin combined with tegio capsules) and control group(n=39) in which totally laparoscopic distal gastrectomy was conducted alone.The operation time,intraoperative bleeding volume,rate of conversion to laparotomy,number of lymph node dissection,postoperative complications,non-operative complications,post-operative staging,recurrence and distant metastasis were retrospectively analyzed in two groups. Results The effective rate was 54.55% (18/33) in observation group,and the post-operative TNM stage was significantly lower than that in control group (P<0.05).The operation time ［(248.0±37.0) min vs (224.9±29.6) min］,intraoperative bleeding ［(139.4±51.7) ml vs (109.6±48.7)ml］ in observation group were statistically higher than those in control group (all P<0.05).There were no significant differences in lymph node dissection number and postoperative complications between two groups(all P＞0.05).The follow-up period ended in October 2017,and the tumor recurrence and metastasis(12.1% vs 41.0%)and mortality(6.0% vs 76.9%)significantly decreased in observation group compared with control group (P<0.05). Conclusion It is concluded that SOX regimen combined totally laparoscopic distal gastrectomy with D2 lymphadenectomy is safe and feasible with less trauma and rapid recovery and has advantage in short-term efficacy.