Abstract:Heart failure（HF）is the end stage of cardiovascular disease. HF with preserved ejection fraction（HFpEF）is a common type of HF，but its diagnosis and treatment are still unclear due to its complex pathogenesis and diverse clinical phenotypes. Research indicates that patients with HFpEF often exhibit elevated levels of branched-chain amino acid（BCAA）and metabolic disturbances.There is increasing evidence that high levels of BCAA can affect cardiac function by activating multiple signalling pathways，leading tofurther deterioration of HFpEF. This article reviews the BCAA metabolism and its role in the pathogenesis of HFpEF，and summarizes the intervention methods for the treatment of HFpEF targeting key enzymes in the BCAA metabolism process，in order to provide new ideas for the treatment of HFpEF.