Abstract:Pancreatic cancer is the most lethal cancer type in the world，with a 5?year survival rate of less than 10%. Furthermore，pancreatic cancer ? associated diabetes mellitus（PCDM）is a group of endocrine diseases secondary to pancreatic cancer and a paraneoplastic phenomenon，and the relationship between the two is intricate，forming a vicious circle. The pathogenesis of the disease is unclear，although many pancreatic cancer patients have an increase in blood glucose soon after，but the clinical diagnosis of pancreatic cancer ? related blood glucose elevation is often misdiagnosed as type 2 diabetes mellitus，which often delays the treatment of the primary pancreatic lesions，and this delay may be fatal for pancreatic cancer patients. Therefore，this paper expounds the possible pathogenesis of PCDM，in order to discover new biomarkers，promote the early diagnosis and treatment of PCDM，improve the quality of life and prolong the survival of patients.