Abstract:Colorectal cancer (CRC) is a common gastrointestinal malignant tumor. The existing treatment options are surgery and targeted therapy, the toxic side effects and recurrence rate are high, and the patient compliance is poor. More and more clinical trials support the effectiveness of Chinese herbal medicine in the prevention and treatment of CRC, which has advantages of high safety and low adverse reactions, showing great potential in the prevention and treatment of CRC. This article reviews the role and mechanism of Chinese herbal medicine and its active components in the treatment of CRC, in order to provide a theoretical basis and reference value for the research and clinical application of Chinese herbal medicine and its active components against CRC.