Abstract:Type 2 diabetes is a reversible disease. The remission of type 2 diabetes is defined as maintaining a glycosylated hemoglobin (HbA1c) level＜6.5% and fasting plasma glucose＜7.0 mmol/L for at least 3 months after discontinuation of glucose-lowering medications. Factors independently associated with diabetes remission include islet autoantibodies, duration of diabetes, body mass index, waist circumference, pancreatic islet function, and baseline HbA1c. Lifestyle interventions, caloric restriction, and weight loss are the primary strategies for inducing and maintaining remission, while pharmacological treatment and metabolic surgery play important roles in achieving remission. The mechanisms of remission primarily involve reducing lipid accumulation, alleviating glucolipotoxicity, and improving insulin resistance and β-cell function.