Abstract:Chronic hyperglycemia in diabetic patients can lead to various complications, severely impacting patients life expectancy and quality of life. The hyperglycemic state in diabetes induces oxidative stress, which in turn generates excessive reactive oxygen species (ROS). These ROS disrupt the balance between oxidation and antioxidation, trigger inflammatory responses, and cause organ damage. This cascade of events leads to diabetic complications such as diabetic nephropathy, diabetic foot, diabetic retinopathy, diabetic cardiovascular disease, and diabetic neuropathy. This review summarizes the role of oxidative stress in the pathogenesis and treatment of these five diabetic complications, providing insights for clinical prevention and management of diabetic complications.