Abstract:Objective To explore the application value and emotional regulation of positive psychological intervention in patients with perioperative pancreatitis undergoing endoscopic retrograde cholangiopancreatography (ERCP) for bile duct stone. Methods From January 2021 to December 2023, 120 patients with perioperative pancreatitis undergoing ERCP for bile duct stone treated in the First Affiliated Hospital of Nanjing Medical University were selected and divided into observation group (60 cases) and control group (60 cases) by random number table method. The control group received routine intervention measures, and the observation group received positive psychological intervention on the basis of the control group. Recovery related indexes (anal defecation time, anal exhaust time, hospital stay) were recorded in the two groups. Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were used to evaluate the anxiety and depression of the patients. The self-care ability of patients was evaluated by self-care Ability Scale (ESCA). The Pittsburgh Sleep Quality Index (PSQI) score was used to evaluate the sleep quality of the patients. Results The hospital stay in the observation group was shorter than that in the control group［(14.26±4.71)d vs (18.82±5.33)d，P＜0.05］. After intervention, compared with control group, HAMA and HAMD scores were lower, the scores of self-concept and sense of self-care were higher, the scores of sleep time, sleep disorder, sleep efficiency and sleep quality were lower in the observation group, and the differences were statistically significant (P＜0.05). Conclusion Positive psychological intervention in patients with pancreatitis in perioperative period of ERCP is beneficial to reduce the anxiety and depression of patients, improve the self-care ability and sleep quality of patients, and promote the recovery of patients.