Abstract:Objective To explore the effect of Qingfutongchang Granule on clinical symptoms, immune function and gastrointestinal function of patients with early postoperative inflammatory small bowel obstruction (EPISBO) after laparoscopic appendectomy. Methods A total of 110 patients with EPISBO after laparoscopic appendectomy in Affiliated Hospital of Shaanxi University of Chinese Medicine from June 2021 to June 2023 were selected and randomly divided into control group and observation group, with 55 cases in each group. The control group was given conventional symptomatic treatment. The observation group was given Qingfu Tongchang Granule by oral administration on the basis of conventional treatment in the control group. The TCM syndrome score (TCMSS), inflammatory indexes ［interleukin-6 (IL-6), tumor necrosis faction-α (TNF-α)］, immune indexes (CD4+, CD8+, CD4+/CD8+), gastrointestinal function (gastrointestinal hormone levels and gastrointestinal function recovery time) before and after treatment, as well as the clinical efficacy and adverse reactions were compared between the two groups. Results The total clinical effective rate in the observation group was higher than that in the control group (92.72% vs 76.36%, χ2=5.636, P＜0.05). After treatment, the TCMSS of the two groups were significantly reduced, and the TCMSS of the observation group was lower than that of the control group (P＜0.05). Compared with control group, the level of motilin significantly increased, the level of gastrin significantly decreased in the observation group (P＜0.05). In addition, the recovery time of gastrointestinal function in the observation group were significantly shorter than those in the control group (P＜0.05). Compared with before treatment, the levels of TNF-α and IL-6 were significantly decreased in the two groups after treatment, and the levels of TNF-α and IL-6 in the observation group were significantly lower than those in the control group (P＜0.05). After treatment, compared with before treatment, the level of CD4+ and CD44/CD8+ of the two groups were significantly increased, and the level of CD8+ was significantly decreased (P＜0.05). Compared with control group, the level of CD4+ and CD4+/CD8+ in observation group were significantly increased, and the level of CD8+ was significantly decreased (P＜0.05). There was no significant difference in the total adverse reaction rate between the two groups (P＞0.05). Conclusion Qingfu Tongchang Granule can effectively improve the clinical efficacy of patients with EPISBO, promote the recovery of gastrointestinal function, improve immune function, inhibit inflammatory response, and have good safety.