Abstract:Objective To analyze the prognostic predictive value of combined serum interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and amyloid A (SAA) tests in elderly patients with sepsis combined with acute lung injury (ALI). Methods From May 2021 to May 2023, 50 elderly patients with sepsis (control group), 50 elderly patients with sepsis complicated with ALI (observation group), and 50 elderly healthy subjects (healthy group) admitted in the Affiliated Elderly Hospital of Chengdu Medical College were selected. Patients in observation group were divided into low-risk group (27 cases, 201-300 mmHg), medium-risk group (15 cases, 101-200 mmHg) and high-risk group (8 cases, ≤100 mmHg) according to oxygenation index (OI), and were divided into survival group (42 cases) and death group (8 cases) according to clinical outcomes. Serum levels of IL-6, hs-CRP, SAA and APACHEⅡ scores were compared between each group. Receiver operating characteristic (ROC) curve was used to analyze the predictive efficacy of serum IL-6, hs-CRP and SAA on death. Results The levels of serum IL-6, hs-CRP, SAA and APACHEⅡ score in observation group were higher than those in control group and healthy group (P＜0.05). The levels of IL-6, hs-CRP, SAA and APACHEⅡ score in high-risk group were higher than those in medium-risk group and low-risk group (P＜0.05). The levels of IL-6, hs-CRP, SAA and APACHEⅡ score in the death group were higher than those in the survival group (P＜0.05). The area under the curve of the combined detection of serum IL-6, hs-CRP and SAA to predict the death of sepsis complicated with ALI was the highest ［0.859, 95%CI (0.812-0.952)］, with the sensitivity of 94.96% and specificity of 90.38%. Conclusion High levels of serum IL-6, hs-CRP, and SAA in elderly sepsis with ALI are closely associated with the severity and prognosis of ALI, and the combined assay can improve the efficacy of predicting the clinical outcome of patients.