Abstract:ObjectiveTo explore the clinical application effect of closed rapid pipeline prefilling method in extracorporeal cardiopulmonary resuscitation (ECPR) patients. Methods A total of 36 ECPR patients with cardiac arrest admitted to the Department of Emergency Medicine of Jiangsu Province Hospital from January 2018 to June 2019 were treated with conventional extracorporeal membrane oxygenation (ECMO) pipeline prefilling method (conventional group), and 78 ECPR patients admitted from September 2019 to December 2021 were treated with modified closed rapid ECMO pipeline prefilling method (modified group). Effects of two prefilling methods on priming effect, patient outcome and priming staff satisfaction were compared. Results Compared with conventional group, the success rate of one-time prefilling was higher (98.7% vs 77.8%, χ²=12.110, P＜0.01), and pre-charge time was shorter ［(10.78±1.76) min vs (19.50±3.20) min, t=18.746, P＜0.01］ in modified group. There was no significant difference in serum neuronal specific enolase (NSE), Glasgow Coma Score (GCS), recovery rate of autonomic circulation and discharge rate between the two groups (〖WTBX〗P〖WTBZ〗＞0.05). Prefilled staff satisfaction in the modified group was higher than that in the conventional group (100.0% vs 83.3%, χ²=10.583, 〖WTBX〗P〖WTBZ〗＜0.01). Conclusion The closed rapid pipeline prefilling method can significantly shorten the clinical pipeline prefilling time of ECPR patients and improve the one-time prefilling success rate. It is a safe, efficient and satisfactory ECMO pipeline prefilling method, which is suitable for ECPR patients with a high demand for timeliness.