Abstract:Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease whose etiology has not been elucidated. The pathogenesis can be summarized as environmental factors acting on genetically susceptible individuals, with the participation of intestinal microorganisms, the imbalance of intestinal immune and damage to the intestinal mucosal barrier, resulting in persistent inflammatory damage to the intestinal mucosa. Gut microbiota is closely related to the development and progression of IBD. Ruminococcus gnavus, as one of the most abundant symbiotic bacteria in the human gut, has been shown to be enriched in IBD and is associated with IBD. This review focuses on the characteristics of Ruminococcus gnavus, its colonization in the intestinal tract and its role in the pathogenesis of IBD, so as to provide new ideas for the study of the pathogenesis and treatment of IBD.