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Received:May 14, 2024 Published Online:July 20, 2024
Received:May 14, 2024 Published Online:July 20, 2024
中文摘要: 胰腺再生（REG）蛋白是由再生基因编码的一组钙依赖性凝集素超家族蛋白。REG蛋白家族作为具有多种功能的分泌型生长因子，在营养代谢、抗凋亡、抗纤维化和抗炎抗菌等方面起着调节作用。自1979年被首次发现至今，REG蛋白家族被证实与糖尿病、炎症和肿瘤等多种疾病息息相关。REG蛋白家族的多种亚型参与糖尿病的不同发病机制。本文旨在综述REG蛋白家族的起源、结构特征、分布模式、在各种类型糖尿病中的发病机制和治疗调控作用，探讨REG蛋白家族在糖尿病预警、诊断、治疗和预后方面的潜在临床应用价值，以期未来更广泛地应用于治疗靶标和生物标志物领域。
Abstract:Pancreatic regenerating (REG) protein belongs to the calcium-dependent lectin superfamily, and is encoded by regenerating gene. As secreted growth factors with multiple functions, REG protein family plays a regulatory role in nutrient metabolism, anti-apoptosis, anti-fibrosis, anti-inflammation and antibacterial. Since 1979, REG protein family has been found to be associated with various diseases, such as diabetes, inflammation and cancer. Several subtypes of REG proteins are involved in different pathogenesis of diabetes. The purpose of this study is to review the origin, structural characteristics, distribution patterns of REG protein family and its pathogenesis and therapeutic regulation in different types of diabetes, and to explore the potential application value of REG protein family in the early warning，diagnosis, treatment and prognosis of diabetes, with a view to its wider application in the fields of therapeutic targets and biomarkers in the future.
keywords: Pancreatic regenerating protein Regeneration of islet beta cell Diabetes mellitus Diabetes of exocrine pancreas Clinical early warning
文章编号： 中图分类号：R587.1 文献标志码：A
基金项目:国家自然科学基金（82170845）
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