Abstract:The Janus kinase (JAK) inhibitors are a collective term for various molecules that inhibit tyrosine kinase, mainly targeting the inhibition of various enzymes and transcription factors involved in the Janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling pathway. It has significant therapeutic effects on a variety of inflammatory immune-related and other dermatosis involved in this pathway, which has become a hot spot in dermatological research. This article mainly reviews the mechanism of action, research progress and precautions of JAK inhibitors in related dermatosises, in order to provide ideas for clinical research and treatment of related dermatosises.