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Received:May 24, 2023 Published Online:January 20, 2024
Received:May 24, 2023 Published Online:January 20, 2024
中文摘要: Janus激酶(JAK)抑制剂是多种抑制酪氨酸激酶的分子的总称,主要针对JAK-信号转导子和转录激活子(JAK-STAT)信号通路所涉及的多种酶及转录因子的抑制,对多种涉及这一通路的炎症免疫相关性及其他皮肤病都有显著疗效,成为目前皮肤病研究的热点。本文主要针对JAK抑制剂在相关皮肤病中的作用机制、研究进展及应用注意事项进行综述,以期为相关皮肤病的临床研究及治疗提供思路。
中文关键词: 皮肤病 Janus激酶信号转导和转录激活因子信号通路 Janus激酶抑制剂 免疫调节
Abstract:The Janus kinase (JAK) inhibitors are a collective term for various molecules that inhibit tyrosine kinase, mainly targeting the inhibition of various enzymes and transcription factors involved in the Janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling pathway. It has significant therapeutic effects on a variety of inflammatory immune-related and other dermatosis involved in this pathway, which has become a hot spot in dermatological research. This article mainly reviews the mechanism of action, research progress and precautions of JAK inhibitors in related dermatosises, in order to provide ideas for clinical research and treatment of related dermatosises.
keywords: Dermatosis Janus kinase and signal transducer and activator of transcription signaling pathway Janus kinase inhibitor Immunoregulation
文章编号: 中图分类号:R758.2 R979.5 文献标志码:A
基金项目:山西省医学重点科研项目(2022143)
Author Name | Affiliation |
WANG Siyu*, NIU Xuping | *Ninth Clinical School of Medicine, Shanxi Medical University, Taiyuan, Shanxi 030000, China |
牛旭平2 | 2. 太原中心医院皮肤科,山西 太原 030009 |
Author Name | Affiliation |
WANG Siyu*, NIU Xuping | *Ninth Clinical School of Medicine, Shanxi Medical University, Taiyuan, Shanxi 030000, China |
牛旭平2 | 2. 太原中心医院皮肤科,山西 太原 030009 |
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