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Received:June 09, 2023 Published Online:January 20, 2024
Received:June 09, 2023 Published Online:January 20, 2024
中文摘要: 卵巢癌是常见的妇科肿瘤之一,其易复发、易转移、易耐药的特性使得患者5年生存率较低。而卵巢癌的转移及耐药机制是一个多步骤、多因素参与的极其复杂的过程。近年来,随着对肿瘤微环境(TME)认识的加深其参与调控肿瘤转移及耐药的作用日益受到重视。本文通过文献调研对卵巢癌TME中的细胞外基质、癌相关成纤维细胞、血管内皮生长因子、免疫相关细胞及分子、脂肪细胞、缺氧诱导因子等在调控卵巢癌转移及耐药方面的作用及研究进展进行归纳总结,希望为卵巢癌转移及耐药机制的深入研究提供线索,从而为临床找到克服卵巢癌耐药的解决方法提供参考依据及启发。
Abstract:Ovarian cancer is one of the common gynecological tumors,and its characteristics of easy recurrence, metastasis and drug resistance make the 5-year survival rate low. The metastasis and drug resistance mechanism of ovarian cancer is an extremely complex process involving multiple steps and factors. In recent years, with the recognition of tumor microenvironment (TME), its role in regulating tumor metastasis and drug resistance has been increasingly valued. This article summarizes the role and research progress of extracellular matrix, cancer-associated fibroblasts, vascular endothelial growth factors, immune related cells and molecules, adipocytes and hypoxia-inducible factors in the regulation of metastasis and drug resistance in ovarian cancer TME through literature investigation, hoping to provide clues for the in-depth study of ovarian cancer metastasis and drug resistance mechanism, so as to provide a theoretical basis and inspiration for finding solutions to overcome drug resistance of ovarian cancer in clinical practice.
keywords: Ovarian cancer Metastasis Resistance Tumour microenvironment Extracellular matrix Cancer-associated fibroblasts Vascular endothelial growth factor Immune related cells and molecules Adipocytes Hypoxia inducible factor
文章编号: 中图分类号:R737.31 文献标志码:A
基金项目:中国科学院合肥肿瘤医院“优秀医学青年人才计划”(YQJH202102)
Author Name | Affiliation |
CHEN Li*, HONG Bo | *Department of Oncology, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui 230000, China |
洪波2 | 2. 中国科学院合肥物质科学研究院健康与医学技术研究所,安徽 合肥 230000 |
Author Name | Affiliation |
CHEN Li*, HONG Bo | *Department of Oncology, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui 230000, China |
洪波2 | 2. 中国科学院合肥物质科学研究院健康与医学技术研究所,安徽 合肥 230000 |
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