Abstract:Immunosuppressive drugs have changed the treatment pattern of patients with advanced colorectal cancer and demonstrated huge survival benefits. Currently, immune drugs approved by the guidelines have been widely used clinically, but the main treatment methods for patients with early and middle colorectal cancer are surgical resection, radiotherapy, chemotherapy, anti-angiogenesis and other comprehensive treatments. The therapeutic status of immunosuppressants in these patients is not yet clear. In this paper, immunotherapy for early-stage and mid-stage microsatellite instability and stability colorectal cancer is reviewed, and the existing and ongoing immunoneoadjuvant therapy or immunocombination therapy models are summarized, hoping that immunotherapy can provide more choices for patients with early-stage and mid-stage colorectal cancer.