Abstract:Blindness is an important means of controlling and avoiding measurement bias in clinical trials. As a key concern in on-site verification of clinical trial data, it is crucial for clinical trial results. However, in double-blind clinical trials where the investigational drug cannot achieve blinding or in single-blind clinical trials where blinding evaluators are established, clinical trial institutions have issues such as incomplete or incomplete blinding maintenace procedure/ standard operation procedure(SOP), insufficient training for researchers on blinding, and insufficient intervention and attention from quality management personnel on blinding. From the perspective of institutional management and combined with the actual situation of our hospital, this article explores the improvement of blind design and the development of blinding maintenance SOP, strengthening researcher training and increasing researchers‘ awareness and sense of responsibility for blinding maintenance, implementing and implementing clinical trial blinding maintenance procedure and SOP, and strengthening the quality management of blinding implementation by institutions, in order to provide reference for maintenance management in clinical trial institutions.