Abstract:Objective To analyze the diagnostic value of combined detection of nerve F-wave conduction velocity(CV) and fasting C-Peptide (FC-P) level in evaluating diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 30 T2DM patients with DPN who were treated at Ma’anshan People's Hospital from September 2020 to June 2022 were selected as the observation group, 30 T2DM patients without DPN were selected as the control group, and 30 healthy volunteers from the same period were recruited as the blank group. The levels of FC-P, 2 h postprandial C peptide (PC-P), fasting blood glucose (FBG), 2 h postprandial blood glucose (PBG) and glycosylated hemoglobin (HbA1c) were compared among the three groups. Nerve conduction velocity (including sensory CV, motor CV) and F-wave CV were compared among the three groups. Binary logistic regression was used to analyze the risk factors of DPN in T2DM patients. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of various indicators for the occurence of DPN. Results Compared with control group and blank group, the serum levels of FC-P and PC-P were lower, and the levels of FBG, PBG and HbA1c were higher in the observation group (P＜0.05). The serum levels of FC-P and PC-P in the control group were lower than those in the blank group, and the levels of FBG, PBG and HbA1c in the control group were higher than those in the blank group (P＜0.05). Sensory CV, motor CV and F-wave CV were the slowest in the observation group, followed by the control group, and the fastest in the blank group (P＜0.05). Binary logistic regression analysis showed that slow F-wave CV of median nerve and low FC-P level were the risk factors for DPN in diabetic patients. When median nerve F-wave CV (cut-off point was 48.05 m/s) combined with FC-P (cut-off point was 1.61 pmol/L), the area under ROC of DPN in patients with early diagnosis of diabetes was 0.819, the sensitivity was 82.60% and the specificity was 88.40%. Conclusion The combined detection of nerve F-wave CV and FC-P level can improve the predictive value of DPN in T2DM patients, and can be used for the diagnosis of early DPN patients.