本文已被:浏览 317次 下载 247次
Received:May 05, 2023 Published Online:November 20, 2023
Received:May 05, 2023 Published Online:November 20, 2023
中文摘要: 胰腺癌的临床症状不明显,大多数患者发现时病情已发展至中晚期,这是由于缺乏可靠的生物标志物以及后腹膜的成像技术分辨率有限引起。因此,寻找胰腺癌早诊断和早发现的生物标志物,已成为临床研究的重中之重。外泌体存在于体液中,包裹了分泌组织来源的DNA、RNA、蛋白和代谢物等。对体液中外泌体的检测可以知晓其来源组织的信息,在体外诊断中具有广泛的应用前景。本研究综述外泌体miRNA检测及联合其他标志物检测在胰腺癌早期诊断的临床应用价值。
Abstract:The clinical symptoms of pancreatic cancer are not obvious, and most patients have developed to the middle and late stage after discovery, which is due to the lack of reliable biomarkers and the limited resolution of retroperitoneal imaging technology. Therefore, finding biomarkers for early diagnosis and early detection of pancreatic cancer has become the top priority of clinical research. Exosomes exist in body fluids and encapsulate DNA, RNA, proteins, and metabolites derived from secreted tissues. The detection of exosome in body fluids can reveal information about their source tissues, and has broad application prospects in in vitro diagnosis. This study reviews the clinical value of miRNA detection and combined detection in the early diagnosis of pancreatic cancer.
keywords: Pancreatic cancer Early detection Exosome microRNA
文章编号: 中图分类号: 文献标志码:A
基金项目:上海市浦东新区卫生系统学科带头人培养计划资助项目(PWRd2021-16)
Author Name | Affiliation |
WANG Yunfeng, XIA Junwei, XU Baiying | Department of General Surgery, Shanghai Pudong New Area People's Hospital, Shanghai 201299, China |
Author Name | Affiliation |
WANG Yunfeng, XIA Junwei, XU Baiying | Department of General Surgery, Shanghai Pudong New Area People's Hospital, Shanghai 201299, China |
引用文本: