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Received:February 20, 2023 Published Online:November 20, 2023
Received:February 20, 2023 Published Online:November 20, 2023
中文摘要: 甲状腺功能减退症（简称甲减）是甲状腺激素缺乏导致的一组临床综合病征，可表现出不同程度的情绪异常或者认知功能下降。近年来有多个研究探讨了甲减和情绪及认知功能之间的关系，但甲减与神经精神疾病发生的作用机制目前并没有一致的结论。本综述主要关注甲减相关焦虑、抑郁和认知受损的发病机制，探讨甲减中情绪调节异常以及认知功能损害的特征性病理生理改变，以期进行有效的预防和治疗。
Abstract:Hypothyroidism is a group of clinical symptoms of thyroid hormone deficiency, which can lead to mood abnormalities or cognitive decline in different degrees. In recent years, several studies have investigated the relationship between hypothyroidism and mood and cognitive functions, but the mechanism of hypothyroidism and the development of neuropsychiatric disorders has not been consistently concluded. This review will focus on pathogenesis of anxiety, depression and cognitive impairment associated with hypothyroidism, in order to explore the characteristic pathophysiological changes of abnormal mood regulation and cognitive impairment in hypothyroidism, so that effective prevention and treatment can be carried out.
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基金项目:国家自然科学基金项目（82060152）；甘肃省人民医院院内科研基金项目（22GSSYD-53）
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