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Received:May 04, 2023 Published Online:October 20, 2023
Received:May 04, 2023 Published Online:October 20, 2023
中文摘要: 目的 分析中性粒细胞明胶酶相关载脂蛋白(NGAL)与高血压患者相关性及临床意义。
方法 回顾性纳入2021年8月至2022年9月福建省立医院南院心内科住院高血压患者244例,以NGAL中位水平为界将其分为低NGAL水平组和高NGAL水平组各122例。测定患者血清NGAL水平并收集肌酐、尿酸、24h动态血压等相关临床指标,分析血清NGAL与各指标间的关系。
结果 高NGAL水平组24h平均收缩压(24hSBP)、白天平均收缩压(dSBP)、夜间平均收缩压(nSBP)、白细胞计数、中性粒细胞计数、肌酐水平、冠心病患病率高于低NGAL水平组(P<0.05)。Spearman相关分析显示NGAL分别与24hSBP、dSBP、nSBP、白细胞计数、中性粒细胞计数、肌酐存在正相关性(r=0.465、0.632、0.632、0.834、0.834、0.632,P<0.01)。单因素线性回归显示,白细胞计数、中性粒细胞计数、肌酐、尿酸、eGFR、24hSBP、nSBP与NGAL相关(P<0.05)。多因素线性回归分析提示,中性粒细胞计数升高是血清NGAL升高的独立影响因素(P<0.05)。
结论 高血压患者中,收缩压水平与NGAL之间存在相关性,中性粒细胞计数升高是NGAL水平升高的影响因素,提示炎症可能参与高血压发生过程,且高NGAL水平的高血压患者更易合并冠心病。
Abstract:ObjectiveTo analyze the relationship between serum neutrophil gelatinase-associated lipocalin(NGAL)and hypertensive patients.
Methods The clinical data of 244 hypertensive patients hospitalized in the Department of Cardiology of the South Hospital of Fujian Provincial Hospital from August 2021 to September 2022 were retrospectively included, and they were divided into 122 cases in the low NGAL level group and 122 cases in the high NGAL level group based on the median NGAL level. The serum NGAL level of patients was measured,and relevant clinical indicators such as creatinine,uric acid,and 24-hour ambulatory blood pressure were collected, and the relationship between serum NGAL and various indexes was analyzed.
Results The 24-hour mean systolic blood pressure (24 hSBP), daytime mean systolic blood pressure (dSBP), nighttime mean systolic blood pressure (nSBP), white blood cell count, neutrophil count, creatinine level and the prevalence of coronary heart disease in the high NGAL level group were higher than those in the low NGAL level group (P<0.05).Spearman correlation analysis showed that NGAL was positively correlated with 24hSBP,dSBP,nSBP,white blood cell count, neutrophil count and creatinine, respectively (r=0.465, 0.632, 0.632, 0.834, 0.834, 0.632, P<0.01).Univariate linear regression showed that white blood cell count, neutrophil count,creatinine, uric acid, eGFR,24hSBP and nSBP were correlated with NGAL(P<0.05). Multivariate linear regression analysis indicated that the increase of neutrophil count was an independent influencing factor for the increase of serum NGAL (P<0.05).
Conclusion There is a correlation between systolic blood pressure level and NGAL in hypertensive patients, and neutrophil count is an influencing factor for the increased NGAL level, suggesting that inflammation may participate in the process of hypertension, and hypertensive patients with high NGAL level are more likely to be complicated with coronary heart disease.
keywords: Hypertension Neutrophil gelatinase-assoicated lipocalin 24-hour ambulatory blood pressure Neutrophil count
文章编号: 中图分类号:R544.1 文献标志码:B
基金项目:国家自然科学基金项目(81873515);福建省自然科学基金项目(2020J011072);福建省卫健委医学创新课题(2021CXA008);福建省立医院“创双高”火石基金项目
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