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Received:May 19, 2023 Published Online:October 20, 2023
Received:May 19, 2023 Published Online:October 20, 2023
中文摘要: 目的 探讨艾滋病病毒感染者/艾滋病(HIV/AIDS)患者更换二线抗病毒治疗药物治疗的效果。
方法 按照纳入标准,选取2006至2021年中国疾病预防控制信息系统中的数据,分析潍坊市HIV/AIDS患者更换二线药物治疗前后CD4+、CD8+细胞计数、CD4+/CD8+比值、HIV病毒载量变化情况及相关性。
结果 接受更换二线药物患者共116例。与换药前比,换药1年、2年后,CD4+细胞计数中位数由244.50个/μL上升到360.50个/μL、409.50个/μL (P<0.05);CD8+细胞计数由875.00个/μL上升到981.00个/μL、900.50个/μL,但差异无统计学意义(P>0.05);CD4+/CD8+比值由0.28上升到0.35、0.41 (P<0.01);病毒载量从3 592拷贝/mL降为0(P<0.01)。
结论 艾滋病抗病毒治疗更换二线药物后治疗效果显著,能够促进CD4+细胞的增长和CD4+/CD8+比值的恢复,能够获得较好的免疫恢复和病毒应答。
Abstract:Objective To evaluate the effect of switching to the second-line antiviral therapy drugs in HIV/AIDS patients.
Methods According to the inclusion criteria, the data of HIV/AIDS patients in Weifang from 2006 to 2021 were extracted from China Information System for Disease Control and Prevention, and the changes and correlation of CD4+ and CD8+cell count, CD4+/CD8+ratio and HIV viral load were analyzed and compared before and after switching to the second-line antiviral drugs in HIV/AIDS patients.
Results A total of 116 patients received switching to second-line antiviral therapy. Compared with before switching, after 1 year and 2 years of switching,the median CD4+ cell count increased from 244.50 cells/μL to 360.50 cells/μL and 409.50 cells/μL (P<0.05), CD8+ cell count increased from 875.00 cells/μL to 981.00 cells/μL and 900.50 cells/μL, with no significant difference (P>0.05), the ratio of CD4+/CD8+ increased from 0.28 to 0.35 and 0.41 (P<0.01), and the viral load reduced from 3 592 copies/mL to 0 (P<0.01), respectively.
Conclusion For HIV/AIDS patients, the effect of switching to the second-line antiviral therapy drugs is obvious, which can promote the growth of CD4+cells and the recovery of CD4+/CD8+ratio, and can obtain better immune recovery and virus load response.
keywords: Human immunodeficiency virus infected/acquired immunodeficiency syndrome patient Second-line antiviral therapy drugs CD4+ T lymphocyte CD8+T lymphocyte CD4+/CD8+ ratio Viral load
文章编号: 中图分类号:R512.91 文献标志码:B
基金项目:山东省医药卫生科技发展计划项目(2017WS745);潍坊市卫生健康委员会科研项目计划(WFWSJK-2020-224)
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