Abstract:Objective To investigate the clinical characteristics and prognostic factors affecting elderly patients with sepsis in intensive care unit (ICU) and provide clinical reference for reducing mortality of elderly patients with sepsis. Methods A total of 95 elderly patients with sepsis admitted to the 940 Hospital of Joint Logistic Support Force of PLA from January 2021 to December 2022 were retrospectively selected. The patients were divided into survival group (48 patients) and death group (47 patients) according to their survival status 28 days after admission to ICU. The differences of clinical features between the two groups were compared, and the prognostic factors of elderly patients with sepsis were analyzed by a multivariate logistic regression model. Results Logistic regression analysis showed that low oxygenation index, multiple organ dysfunction (MODS) and septic shock, and high acute physiological and chronic health evaluation Ⅱ (APACHE Ⅱ) scores were independent risk factors for 28-day prognosis in elderly patients with sepsis (OR=6.309, 12.001, 4.768, P＜0.05)， and high oxygenation index was a protective factor (OR=0.176, P＜0.01). The area under ROC curve for oxygenation index, MODS, septic shock and APACHE Ⅱ scores to predict poor prognosis in elderly septic patients were 0.790, 0.875, 0.614 and 0.736, respectively. Conclusion Low oxygenation index, complicated with MODS and septic shock, and high APACHE Ⅱ score are independent risk factors affecting the prognosis of elderly septic patients in ICU, and have good predictive value for their prognosis.