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Received:September 25, 2023 Published Online:October 20, 2023
Received:September 25, 2023 Published Online:October 20, 2023
中文摘要: 脓毒症是ICU死亡的主要原因,其可以引起多器官功能障碍,其中肺是最容易受累的靶器官。脓毒症早期会出现炎症因子风暴, 炎症、内皮系统和氧化应激反应加重肺损伤,导致急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)。许多免疫细胞和非免疫细胞参与脓毒症肺损伤的发生和发展。但目前脓毒症相关肺损伤的发病机制仍未完全阐明。本文从ALI的病理学、肺直接损伤和间接损伤、先天免疫系统的补体损伤、脓毒症肺损伤相关细胞的变化、细胞焦亡及治疗潜在策略等方面阐述脓毒症肺损伤的发病机制和治疗展望。
Abstract:Sepsis is the leading cause of ICU mortality, and can cause multi-organ dysfunction, of which the lung is the most vulnerable target organ. A storm of inflammatory factors occurs in early sepsis, and the inflammation, endothelial system and oxidative stress aggravate lung injury, leading to acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS). Many immune and non-immune cells are involved in the onset and progression of septic lung injury. Due to the complexity of the mechanisms, there is a lack of systematic understanding of the mechanisms of septic lung injury. This article expounds the pathogenesis and treatment outlook of septic lung injury from the aspects of pathology, direct lung injury and indirect lung injury, complement damage of the innate immune system, changes of cells related to septic lung injury, pyroptosis and potential treatment strategies.
keywords: Sepsis Acute lung injury Acute respiratory distress syndrome Complement damage of the innate immune system Pulmonary epithelial cells Alveolar macrophage Innate lymphoid cells Pyroptosis
文章编号: 中图分类号:R631 文献标志码:A
基金项目:辽宁民生科技计划联合规划项目(2021JH2/10300107)
Author Name | Affiliation |
FU Xuzhe, WANG Yu | Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China |
Author Name | Affiliation |
FU Xuzhe, WANG Yu | Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China |
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