Abstract:Objective To investigate the efficacy and safety of fractional micro ablative laser combined with estriol cream in the treatment of postmenopausal mild to moderate stress urinary incontinence（SUI）. Methods Postmenopausal patients（220 cases） with mild to moderate SUI in Sichuan Jinxin Women & Children Hostipal and the Third People's Hospital of Chengdu from January 2020 to January 2022 were randomly divided into the control group（n=110） and the study group（n=110）. The patients in the control group were treated with fractional micro ablative laser, while the patients in the study group was additionally given estriol cream. The patients were followed up for 6 months. The clinical efficacy, 1h urine leakage, urinary incontinence symptom score, quality of life score, self rating anxiety scale（SAS）, self rating depression scale（SDS） score, endometrial thickness changes and adverse reactions were compared between two groups. Results One patient was lost to follow up in control group. Compared with control group, the total effective rate was higher（84.55% vs 73.39%, P＜0.05）, the 1h urine leakage was less ［（1.96±0.78）g vs （2.56±1.14）g， P＜0.05］, the quality of life score was higher, the scores of urinary incontinence symptoms, SAS and SDS were lower （P＜0.05） in the study group. There was no significant difference in the incidence of adverse reactions and endometrial thickness during treatment and follow up （P＞0.05）. Conclusion Fractional micro ablative laser combined with estriol cream in the treatment of mild to moderate postmenopausal SUI can improve the effective rate and the quality of life of patients, relieve anxiety and depression, have long treatment intervals, convenience and high safety.